Goals
The Animal Models and Experimental Systems Component is responsible for developing, maintaining and producing animal and cell culture models of angiogenesis for study. These models are applied to study the variation in angiogenic phenotypes of consomic rats. The vascular endothelial cells cultured for these studies receive either in vivo electrical stimulation of the muscle surrounding the vessels containing the cells, or in vitro stimulation by hypoxia or MatriGel™ Basement Membrane Matrix.
Milestones: 10/1/2002 - 05/18/2005
The milestones listed from October 1, 2002 to May 18, 2005 were to set up the lab, and to produce cells from 6 consomic strains of rats for study by the Proteomics and Technology Development Component (Component 1) and the Protein Analysis and Technology Implementation Component (Component 3).
View cell images
| Vascular Endothelial Cells Isolated and Cultured Through January 2007 |
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Strain
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Matrigel ™
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Hypoxia
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Electrical Stimulation
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Sprague-Dawley (SD)
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X
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X
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Dahl Salt Sensitive (SS)
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X
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X
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X
|
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Brown Norway (BN)
|
X
|
X
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X
|
|
SS.BN.2
|
X
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X
|
|
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SS.BN.3
|
|
X
|
|
|
SS.BN.4
|
|
|
X
|
|
SS.BN.6
|
X
|
X
|
|
|
SS.BN.7
|
X
|
X
|
|
|
SS.BN.9
|
X
|
X
|
|
|
SS.BN.10
|
|
X
|
|
|
SS.BN.11
|
X
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X
|
X
|
|
SS.BN.13
|
X
|
X
|
X
|
|
SS.BN.14
|
|
|
X
|
|
SS.BN.16
|
X
|
X
|
X
|
|
SS.BN.18
|
X
|
X
|
X
|
|
SS.BN.20
|
X
|
X
|
X
|
|
SS.BN.Y
|
|
X
|
|
