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MCW Proteomics Center Overview

The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, has launched a major initiative to develop innovative proteomic technologies by creating 10 special centers of research, each funded for 7 years. Proteomics is the study of all or large groups of proteins in cells, tissues, and organs, and how they respond, interact, and change. Each new center will focus on different novel technologies related to some aspect of healthy and diseased heart, lung, blood, and/or sleep processes. Ultimately, the research is expected to yield new and improved ways to diagnose and treat heart, lung, blood, and sleep disorders.

The MCW Proteomics Center will develop mass spectrometric methodologies and technology for the quantitative analysis of the entire proteome of a single cell. The goal is to dramatically increase the sensitivity, resolution and mass range of the analysis process and develop approaches for the processing of single cells into a form suitable for mass spectrometric analysis of their components. The bioinformatics component concentrates on data management and warehousing and novel data analysis and data mining algorithms.

The complete list of proteomics centers funded by this initiative:

• Three-D Proteomics and Aptemeric Arrays for Cystic Fibrosis at the Henry M. Jackson Foundation for the Advancement of Military Medicine, in Rockville, MD
  
• Cardiovascular Proteomics Center at the Medical University of South Carolina in Charleston
  
• Development of Novel Mass Spectrometry Tools for Individual Cell Proteome Analysis at the Medical College of Wisconsin in Milwaukee
  
• NHLBI Proteomics Center at Yale University in New Haven, CT
  
• NHLBI Proteomics Center at The Institute for Systems Biology in Seattle, WA
  
• Oxidative Protein Modifications in Cardiovascular Disease at Boston University in MA
  
• Proteomic Analysis of Blood Components in Autoimmune Disease at Stanford University in Stanford, CA
  
• Proteomic Technologies to Study Airway Inflammation at the University of Texas Medical Branch at Galveston
  
• Proteomics of Adaptation to Ischemia/Hypoxia in the Heart, Lung, and Blood at The Johns Hopkins University School of Medicine in Baltimore, MD
  
• Southwestern Center for Proteomics Research at the University of Texas Southwestern Medical Center in Dallas

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